Reprogramming: faithful reporters

A protein roadmap to pluripotency and faithful reprogramming.

Embryonic stem (ES) cells are of great interest because of their capability of unlimited self-renewal and multilineage differentiation, thus serving as a potentially unlimited source for tissue replacement in regenerative medicine. ES cells possess factors that maintain and induce pluripotency, as demonstrated by successful reprogramming of somatic cells by fusion with ES cells. Understanding t...

Faithful reprogramming to pluripotency in mammals - what does nuclear transfer teach us?

Nuclear reprogramming toward pluripotency has been now achieved either in vivo by somatic cell nuclear transfer into the ooplasm of an enucleated egg, or in vitro by three different approaches, namely cell fusion, treatment with cell extracts and more recently, forced expression of a reduced set of defined transcription factors. This last technique has expanded our view of genome plasticity wit...

Optogenetic reporters.

The discovery of naturally evolved fluorescent proteins and their subsequent tuning by protein engineering provided the basis for a large family of genetically encoded biosensors that report a variety of physicochemical processes occurring in living tissue. These optogenetic reporters are powerful tools for live-cell microscopy and quantitative analysis at the subcellular level. In this review,...

Old faithful.

Faithful Squashed Entanglement

Squashed entanglement is a measure for the entanglement of bipartite quantum states. In this paper we present a lower bound for squashed entanglement in terms of a distance to the set of separable states. This implies that squashed entanglement is faithful, that is, it is strictly positive if and only if the state is entangled. We derive the lower bound on squashed entanglement from a lower bou...